METABASE 30M SERIES INSIGHT PDF

125000000217 alkyl group Chemical group 0.000 claims description 101.

229910003667 SRa Inorganic materials 0.000 claims description 101.

125000001072 heteroaryl group Chemical group 0.000 claims description 102.

125000003118 aryl group Chemical group 0.000 claims description 103.

229910052739 hydrogen Inorganic materials 0.000 claims description 123.

150000001875 compounds Chemical class 0.000 claims description 139.

229910003827 NRaRb Inorganic materials 0.000 claims description 204.

229910004664 ORa Inorganic materials 0.000 claims description 309.

229910004755 ORb Inorganic materials 0.000 claims description 356.

229910003813 NRa Inorganic materials 0.000 claims description 560.

201000004681 psoriasis Diseases 0.000 claims abstract description 3.

206010023230 Joint stiffness Diseases 0.000 claims abstract description 3.

210000000987 Immune System Anatomy 0.000 claims abstract description 3.

235000020824 obesity Nutrition 0.000 claims abstract description 5.

208000008589 Obesity Diseases 0.000 claims abstract description 5.206010012601 Diabetes mellitus Diseases 0.000 claims abstract description 6.239000005483 tyrosine kinase inhibitor Substances 0.000 claims abstract description 10.201000011510 cancer Diseases 0.000 claims abstract description 13.108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims abstract description 13.102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims abstract description 13.239000003934 phosphoprotein phosphatase inhibitor Substances 0.000 claims abstract description 21.239000003909 protein kinase inhibitor Substances 0.000 claims abstract description 33.108090000623 proteins and genes Proteins 0.000 claims abstract description 45.102000004169 proteins and genes Human genes 0.000 claims abstract description 45.230000000694 effects Effects 0.000 claims abstract description 97.108060006633 Protein Kinases Proteins 0.000 title claims abstract description 100.102000001253 Protein Kinases Human genes 0.000 title claims abstract description 108.239000003112 inhibitor Substances 0.000 title claims abstract description 328.230000002401 inhibitory effect Effects 0.000 title claims abstract description 421.Publication of US20060030544A1 publication Critical patent/US20060030544A1/en Application granted granted Critical Publication of US7772216B2 publication Critical patent/US7772216B2/en Status Active legal-status Critical Current Adjusted expiration legal-status Critical Links

Assignors: MILKIEWICZ, KAREN, EL-ARABY, MOUSTAFA, HANGAUER, JR., DAVID G. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to US33619101P priority Critical Priority to US10/277,217 priority patent/US7005445B2/en Application filed by Research Foundation of State University of New York filed Critical Research Foundation of State University of New York Priority to US11/206,115 priority patent/US7772216B2/en Assigned to RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE reassignment RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee Research Foundation of State University of New York Priority date (The priority date is an assumption and is not a legal conclusion. Research Foundation of State University of New York Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) ( en Inventor David Hangauer Moustafa El-Araby Karen Milkiewicz Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number US11/206,115 Other versions US7772216B2

METABASE 30M SERIES INSIGHT PDF

Google Patents Protein kinase and phosphatase inhibitors and methods for designing themĭownload PDF Info Publication number US20060030544A1 US20060030544A1 US11/206,115 US20611505A US2006030544A1 US 20060030544 A1 US20060030544 A1 US 20060030544A1 US 20611505 A US20611505 A US 20611505A US 2006030544 A1 US2006030544 A1 US 2006030544A1 Authority US United States Prior art keywords group aryl biaryl heteroaryl cyclic Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US20060030544A1 - Protein kinase and phosphatase inhibitors and methods for designing them US20060030544A1 - Protein kinase and phosphatase inhibitors and methods for designing them

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